Chris Sprouse posted this on his Facebook recently:
"Unfinished inks/inked linework. When doing color pieces, I use pretty heavy, nearly opaque watercolors sometimes, and certain colors will just sit on top of the black ink. For that reason it's better to fill in all the solid black areas after all the colors are applied and dry."
"Colors, done using brush and watercolors. There are actually clouds and some light blue sky in the final drawing, but I did this piece in a hotel room after hours at a convention and was at the mercy of the crappy Kinko's scanner I had to use to capture it the next day. The blue just didn't reproduce at all."